Etiology of secondary hypertension drug induced hypertension

from wikipedia.org

Only in a small minority of patients with elevated arterial pressure, can a specific cause be identified. drug induced hypertension These individuals will probably have an endocrine or renal defect that, if corrected, could bring blood pressure back to normal values.

Renal hypertension  drug induced hypertension

Hypertension produced by diseases of the kidney. This includes diseases such as polycystic kidney disease or chronic glomerulonephritis. Hypertension can also be produced by diseases of the renal arteries supplying the kidney. This is known as renovascular hypertension; drug induced hypertension it is thought that decreased perfusion of renal tissue due to stenosis of a main or branch renal artery activates the renin-angiotensin system.

Adrenal hypertension

Hypertension is a feature of a variety of adrenal cortical abnormalities. drug induced hypertension In primary aldosteronism there is a clear relationship between the aldosterone-induced sodium retention and the hypertension.

In patients with pheochromocytoma increased secretion of catecholamines such as epinephrine and norepinephrine by a tumor drug induced hypertension (most often located in the adrenal medulla) causes excessive stimulation of [adrenergic receptors], which results in peripheral vasoconstriction and cardiac stimulation. This diagnosis is confirmed by demonstrating increased urinary excretion of epinephrine and norepinephrine and/or their metabolites drug induced hypertension (vanillylmandelic acid).

Coarctation of the aorta

Diet

The North American diet that is high in fat and salt has been proven to exacerbate hypertension. drug induced hypertension A study in the U.S. found that patients placed on a strict vegetarian diet showed a significant benefit to their condition over the one year. Certain medications, especially NSAIDS (Motrin/ibuprofen) and steroids can cause hypertension. drug induced hypertension Imported licorice (Glycyrrhiza glabra) inhibits the 11-hydroxysteroid hydrogenase enzyme (catalyzes the reaction of cortisol to cortison) drug induced hypertension which allows cortisol to stimulate the Mineralocorticoid Receptor (MR) which will lead to effects similar to hyperaldosteronism, which itself is a cause of hypertension. drug induced hypertension [Reference: Harrisons Internal Medicine, online edition (2007-04-14)]

Age

Over time, the number of collagen fibers in artery and arteriole walls increases, drug induced hypertension making blood vessels stiffer. With the reduced elasticity comes a smaller cross-sectional area in systole, and so a raised mean arterial blood pressure.

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