The Etiology Of Hypertension
 

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Etiology of secondary hypertension effects of hypertension

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Only in a small minority of patients with elevated arterial pressure, can a specific cause be identified. effects of hypertension These individuals will probably have an endocrine or renal defect that, if corrected, could bring blood pressure back to normal values.

Renal hypertension  effects of hypertension
Hypertension produced by diseases of the kidney. This includes diseases such as polycystic kidney disease or chronic glomerulonephritis. Hypertension can also be produced by diseases of the renal arteries supplying the kidney. This is known as renovascular hypertension; effects of hypertension it is thought that decreased perfusion of renal tissue due to stenosis of a main or branch renal artery activates the renin-angiotensin system.
Adrenal hypertension
Hypertension is a feature of a variety of adrenal cortical abnormalities. effects of hypertension In primary aldosteronism there is a clear relationship between the aldosterone-induced sodium retention and the hypertension.
In patients with pheochromocytoma increased secretion of catecholamines such as epinephrine and norepinephrine by a tumor effects of hypertension (most often located in the adrenal medulla) causes excessive stimulation of [adrenergic receptors], which results in peripheral vasoconstriction and cardiac stimulation. This diagnosis is confirmed by demonstrating increased urinary excretion of epinephrine and norepinephrine and/or their metabolites effects of hypertension (vanillylmandelic acid).
Coarctation of the aorta
Diet
The North American diet that is high in fat and salt has been proven to exacerbate hypertension. effects of hypertension A study in the U.S. found that patients placed on a strict vegetarian diet showed a significant benefit to their condition over the one year. Certain medications, especially NSAIDS (Motrin/ibuprofen) and steroids can cause hypertension. effects of hypertension Imported licorice (Glycyrrhiza glabra) inhibits the 11-hydroxysteroid hydrogenase enzyme (catalyzes the reaction of cortisol to cortison) effects of hypertension which allows cortisol to stimulate the Mineralocorticoid Receptor (MR) which will lead to effects similar to hyperaldosteronism, which itself is a cause of hypertension. effects of hypertension [Reference: Harrisons Internal Medicine, online edition (2007-04-14)]
Age
Over time, the number of collagen fibers in artery and arteriole walls increases, effects of hypertension making blood vessels stiffer. With the reduced elasticity comes a smaller cross-sectional area in systole, and so a raised mean arterial blood pressure.

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Considerations of Class Effect in Hypertension and CVD
Domenic A. Sica, MD, updates the concept of class effects of beta-blockers and ACE inhibitors in the context of recent studies.

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Hypertension Introduction
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Researchers' discovery may lead to hypertension treatment (PhysOrg)
For more than 40 years, researchers have suspected there must be a natural hormone that could safely flush sodium out of the body and could be harnessed to develop more effective and safer treatments for high blood pressure, or hypertension. Currently, drugs that lower sodium levels all have serious side effects because they also reduce potassium levels.

Hypertension Patients' Risk For Diabetes May Be Decreased By Preventing Or Reducing Enlarged Heart (Medical News Today)
High-blood-pressure patients treated for enlarged heart (left ventricular hypertrophy, LVH) who have regression or prevention of LVH may also have a better chance of preventing diabetes. Led by physician-scientists at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, the research is published in the November Hypertension, a journal of the American Heart Association (AHA). [click link ...

UPDATE: Nebivolol Lowers Blood Pressure in African Americans With Stage I-II Hypertension as Demonstrated in a Study ... (PR Newswire via Yahoo! Finance)
Forest Laboratories, Inc. today announced the results of a double-blind, randomized, placebo-controlled clinical trial, published in the November 2007 issue of the Journal of Clinical Hypertension, which demonstrated that nebivolol significantly reduced sitting diastolic and systolic blood pressure used as monotherapy among African-American patients with stage I-II hypertension.

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