The Etiology Of Hypertension
 

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Etiology of secondary hypertension hypertension clinical

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Only in a small minority of patients with elevated arterial pressure, can a specific cause be identified. hypertension clinical These individuals will probably have an endocrine or renal defect that, if corrected, could bring blood pressure back to normal values.

Renal hypertension  hypertension clinical
Hypertension produced by diseases of the kidney. This includes diseases such as polycystic kidney disease or chronic glomerulonephritis. Hypertension can also be produced by diseases of the renal arteries supplying the kidney. This is known as renovascular hypertension; hypertension clinical it is thought that decreased perfusion of renal tissue due to stenosis of a main or branch renal artery activates the renin-angiotensin system.
Adrenal hypertension
Hypertension is a feature of a variety of adrenal cortical abnormalities. hypertension clinical In primary aldosteronism there is a clear relationship between the aldosterone-induced sodium retention and the hypertension.
In patients with pheochromocytoma increased secretion of catecholamines such as epinephrine and norepinephrine by a tumor hypertension clinical (most often located in the adrenal medulla) causes excessive stimulation of [adrenergic receptors], which results in peripheral vasoconstriction and cardiac stimulation. This diagnosis is confirmed by demonstrating increased urinary excretion of epinephrine and norepinephrine and/or their metabolites hypertension clinical (vanillylmandelic acid).
Coarctation of the aorta
Diet
The North American diet that is high in fat and salt has been proven to exacerbate hypertension. hypertension clinical A study in the U.S. found that patients placed on a strict vegetarian diet showed a significant benefit to their condition over the one year. Certain medications, especially NSAIDS (Motrin/ibuprofen) and steroids can cause hypertension. hypertension clinical Imported licorice (Glycyrrhiza glabra) inhibits the 11-hydroxysteroid hydrogenase enzyme (catalyzes the reaction of cortisol to cortison) hypertension clinical which allows cortisol to stimulate the Mineralocorticoid Receptor (MR) which will lead to effects similar to hyperaldosteronism, which itself is a cause of hypertension. hypertension clinical [Reference: Harrisons Internal Medicine, online edition (2007-04-14)]
Age
Over time, the number of collagen fibers in artery and arteriole walls increases, hypertension clinical making blood vessels stiffer. With the reduced elasticity comes a smaller cross-sectional area in systole, and so a raised mean arterial blood pressure.

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UPDATE: Nebivolol Lowers Blood Pressure in African Americans With Stage I-II Hypertension as Demonstrated in a Study ... (PR Newswire via Yahoo! Finance)
Forest Laboratories, Inc. today announced the results of a double-blind, randomized, placebo-controlled clinical trial, published in the November 2007 issue of the Journal of Clinical Hypertension, which demonstrated that nebivolol significantly reduced sitting diastolic and systolic blood pressure used as monotherapy among African-American patients with stage I-II hypertension.

Arete Therapeutics Initiates Phase 1 Clinical Trial For AR9281 as a First-in-Class Antihypertensive Agent (PR Newswire via Yahoo! Finance)
Arete Therapeutics Inc. today announced the initiation of a phase 1 clinical trial for its lead compound, AR9281, for the treatment of hypertension.

Scientists find way to 'switch off' hypertension (IANS via Yahoo! India News)
New York, Nov 2 (IANS) In a finding that has implications for the treatment of hypertension, researchers have identified what they believe is the 'master switch' that regulates blood pressure.

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